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pentobarbital will lessen the extent or effect of ramelteon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unidentified.Contraindicated (1)pentobarbital will lessen the level or outcome of roflumilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital raises toxicity of ifosfamide by influencing hep